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CSF monoamine metabolites in child and adult psychiatric patients. A developmental perspective.
- Source :
-
Archives of general psychiatry [Arch Gen Psychiatry] 1980 Jun; Vol. 37 (6), pp. 677-81. - Publication Year :
- 1980
-
Abstract
- Concentrations of acid metabolites of dopamine and serotonin were measured in lumbar CSF of a diagnostically heterogeneous group of 154 psychiatric patients following oral probenecid loading. The patients ranged in age from 2 to 67 years old. No patients had received psychoactive medications for at least two weeks prior to the lumbar puncture. Children had higher mean CSF homovenillic acid (HVA) levels, higher mean CSF HVA-probenecid ratios, higher CSF HVA-log probenecid ratios, and lower mean CSF probenecid levels than adults. Age was negatively correlated with CSF HVA level and with CSF HVA-probenecid ratio. These correlations were more pronounced in male patients than in female patients.
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Autistic Disorder cerebrospinal fluid
Bipolar Disorder cerebrospinal fluid
Child
Child, Preschool
Cognition Disorders cerebrospinal fluid
Female
Humans
Male
Middle Aged
Perceptual Disorders cerebrospinal fluid
Probenecid cerebrospinal fluid
Schizophrenia cerebrospinal fluid
Homovanillic Acid cerebrospinal fluid
Hydroxyindoleacetic Acid cerebrospinal fluid
Mental Disorders cerebrospinal fluid
Phenylacetates cerebrospinal fluid
Subjects
Details
- Language :
- English
- ISSN :
- 0003-990X
- Volume :
- 37
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Archives of general psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 6155891
- Full Text :
- https://doi.org/10.1001/archpsyc.1980.01780190075009