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Antibody to hepatitis B virus induced by injecting antibodies to the idiotype.
- Source :
-
Science (New York, N.Y.) [Science] 1984 Mar 02; Vol. 223 (4639), pp. 930-1. - Publication Year :
- 1984
-
Abstract
- Anti-idiotype reagents that recognize a common idiotype associated with antibody to hepatitis B surface antigen (anti-HBs) were used to induce anti-HBs in mice. The anti-idiotype-induced anti-HBs was found to recognize the group-specific a determinant of hepatitis B surface antigen and to express an interspecies idiotype. These findings suggest that anti-idiotypes may be useful as vaccines or vaccine primers.
- Subjects :
- Animals
Cross Reactions
Epitopes immunology
Hepatitis B Antibodies immunology
Hepatitis B Surface Antigens classification
Immunization, Passive
Mice
Mice, Inbred BALB C
Species Specificity
Hepatitis B Antibodies biosynthesis
Hepatitis B Surface Antigens immunology
Immunoglobulin Idiotypes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 223
- Issue :
- 4639
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 6198721
- Full Text :
- https://doi.org/10.1126/science.6198721