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Identification of three class II antigens, DR7, MB2, and MT3, from a homozygous human cell line.
- Source :
-
Human immunology [Hum Immunol] 1984 Mar; Vol. 9 (3), pp. 159-74. - Publication Year :
- 1984
-
Abstract
- The class II antigens from a homozygous DR7 human B cell line were isolated by immunoprecipitation with human alloantisera or monoclonal antibodies. Three class II light chains and three class II heavy chains were identified. The heavy and light chain subunits of the DR7 antigen were distinct from those of the MB2 antigen as assessed by two-dimensional gel electrophoresis. A third light chain in addition to the DR7 and MB2 subunits was precipitated by some alloantisera containing MT3 antibodies. The monoclonal antibodies examined immunoprecipitated one or more of the three class II antigens. The MB2 antigen appeared to be the same as the major antigen recognized by L227 and the DS7 antigen precipitated by SG171.
- Subjects :
- Antibodies, Monoclonal immunology
Antigen-Antibody Reactions
B-Lymphocytes immunology
Cell Line
Chemical Precipitation
Epitopes analysis
Epitopes immunology
Epitopes isolation & purification
Genes, MHC Class II
HLA-DR Antigens
HLA-DR7 Antigen
Histocompatibility Antigens Class II immunology
Homozygote
Humans
Isoantibodies immunology
Histocompatibility Antigens Class II isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 0198-8859
- Volume :
- 9
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Human immunology
- Publication Type :
- Academic Journal
- Accession number :
- 6199337
- Full Text :
- https://doi.org/10.1016/0198-8859(84)90043-0