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Effect of oral 13-cis-retinoic acid on serum lipids.
- Source :
-
The British journal of dermatology [Br J Dermatol] 1982 Nov; Vol. 107 (5), pp. 591-5. - Publication Year :
- 1982
-
Abstract
- Serum lipid concentrations were measured in eighteen patients with severe acne before, during and after treatment with 0.8 mg/kg 13-cis-retinoic acid for 3 months. Cholesterol and triglyceride concentrations increased and HDL-cholesterol concentrations fell significantly during therapy. There were significant abnormalities of liver function and small decreases in indices of thyroid function. These changes had reverted to normal by 1 month after treatment. The data suggest that use of the drug in acne is likely to be limited by its toxicity.
- Subjects :
- Acne Vulgaris blood
Administration, Oral
Adolescent
Adult
Cholesterol blood
Cholesterol, HDL
Female
Humans
Isotretinoin
Lipoproteins, HDL blood
Liver drug effects
Male
Thyroid Gland drug effects
Tretinoin administration & dosage
Tretinoin adverse effects
Triglycerides blood
Acne Vulgaris drug therapy
Lipids blood
Tretinoin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0007-0963
- Volume :
- 107
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The British journal of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 6215057
- Full Text :
- https://doi.org/10.1111/j.1365-2133.1982.tb00411.x