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Indirect evidence that the action of cyproterone acetate on the skin is due to a metabolite.
- Source :
-
Clinical endocrinology [Clin Endocrinol (Oxf)] 1983 Jul; Vol. 19 (1), pp. 53-5. - Publication Year :
- 1983
-
Abstract
- Cyproterone acetate, applied as 1% solution in ethanol or isopropyl myristate, did not decrease the sebum excretion rate (SER) when applied to forehead skin of patients with acne, although SER is decreased when the drug is given systemically. The probable explanation is that cyproterone acetate owes its local action to a metabolite formed systemically. The present study shows this is unlikely to be the 17 beta-hydroxy cyproterone acetate.
- Subjects :
- Acne Vulgaris drug therapy
Administration, Topical
Cyproterone pharmacology
Cyproterone therapeutic use
Cyproterone Acetate
Ethanol
Female
Humans
Male
Myristates
Pharmaceutical Vehicles
Secretory Rate drug effects
Acne Vulgaris physiopathology
Cyproterone analogs & derivatives
Sebum metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0300-0664
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 6225571
- Full Text :
- https://doi.org/10.1111/j.1365-2265.1983.tb00742.x