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Effect of subcutaneously administered 2,6,10,14-tetramethylpentadecane on plasmacytoma growth.
- Source :
-
Cancer research [Cancer Res] 1980 Jul; Vol. 40 (7), pp. 2229-33. - Publication Year :
- 1980
-
Abstract
- 2,6,10,14-Tetramethylpentadecane (pristane), s.c. injected simultaneously with plasmacytoma inocula, enhances the transplantability of tumor cells. The effect is dose and time dependent. The enhancement is shown only by plasmacytoma (MOPC-315 and MPC-11) and not by the murine lymphosarcoma and chondrosarcoma tested. Various mechanisms, such as stress and depression of humoral and cellular immunity, have been considered.
- Subjects :
- Adrenocorticotropic Hormone pharmacology
Animals
Antibody Formation drug effects
Cell Division drug effects
Chondrosarcoma immunology
Chondrosarcoma pathology
Drug Administration Schedule
Female
Injections, Subcutaneous
Lymphoma, Non-Hodgkin immunology
Lymphoma, Non-Hodgkin pathology
Mice
Mice, Inbred BALB C
Mitogens pharmacology
Neoplasm Transplantation
Neoplasms, Experimental immunology
Neoplasms, Experimental pathology
Plasmacytoma pathology
Spleen drug effects
Spleen immunology
T-Lymphocytes drug effects
T-Lymphocytes immunology
Terpenes administration & dosage
Terpenes antagonists & inhibitors
Graft Enhancement, Immunologic
Plasmacytoma immunology
Terpenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0008-5472
- Volume :
- 40
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Cancer research
- Publication Type :
- Academic Journal
- Accession number :
- 6248200