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Comparative in-vitro activity of selected new beta-lactam antimicrobials against Neisseria gonorrhoeae.
- Source :
-
The British journal of venereal diseases [Br J Vener Dis] 1982 Aug; Vol. 58 (4), pp. 228-30. - Publication Year :
- 1982
-
Abstract
- Four new beta-lactam antimicrobials, ceftriaxone, cefotiam, cefonicid, and mecillinam, were evaluated in vitro against 72 beta-lactamase-negative and 26 beta-lactamase-positive isolates of Neisseria gonorrhoeae. Ceftriaxone was the most active of the antimicrobials tested. It inhibited all isolates, regardless of beta-lactamase activity, at a concentration of less than or equal to 0.015 microgram/ml. Cefotiam and cefonicid were also active against both groups but not as active as ceftriaxone. Both groups of N gonorrhoeae showed a high degree of resistance against mecillinam.
- Subjects :
- Amdinocillin pharmacology
Cefamandole analogs & derivatives
Cefamandole pharmacology
Cefonicid
Cefotaxime analogs & derivatives
Cefotaxime pharmacology
Cefotiam
Ceftriaxone
Microbial Sensitivity Tests
Neisseria gonorrhoeae enzymology
beta-Lactamases metabolism
Anti-Bacterial Agents pharmacology
Neisseria gonorrhoeae drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0007-134X
- Volume :
- 58
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The British journal of venereal diseases
- Publication Type :
- Academic Journal
- Accession number :
- 6286034
- Full Text :
- https://doi.org/10.1136/sti.58.4.228