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[Fundamental and clinical studies of cefotiam in the field of oral surgery].
- Source :
-
The Japanese journal of antibiotics [Jpn J Antibiot] 1982 Sep; Vol. 35 (9), pp. 2219-33. - Publication Year :
- 1982
-
Abstract
- Cefotiam (CTM) is a new synthetic cephem antibiotic developed in Japan. The results of the fundamental and clinical studies are as follows. 1. CTM showed antibacterial activity, in terms of MIC, as strong as those of cephalothin (CET) and cefazolin (CEZ) for Gram-positive cocci, and several times superior to for Gram-negative bacilli. 2. CTM serum levels approximately reached the peaks on completion of 60 minutes intravenous drip infusion of 1 g of this preparation dissolved in 5% glucose solution of 250 ml; the mean value was 65.00 micrograms/ml. Then the levels dropped rather quickly up to 180 minutes after the start of drip infusion. After that, the levels dropped gradually up to 360 minutes. 3. As for the passage of CTM in the oral tissues, satisfactory passage was observed in both maxillomandibular marrow and gingiva, which adequately exceeded MICs of the clinically isolated strains of oral infections. 4. This preparation was administered 1 g of 2 g daily by intravenous drip infusion in 18 cases of moderate or more serious infections in the field of oral surgery; the clinical efficacy rate obtained was 94.4%. 5. No manifestations of side effect were observed clinically. As for laboratory findings, 1 case of large increases in GOT and GTP (a hepatitis B antigen positive patient) and 2 cases of slight increase in GTP were observed. On the basis of these results of the fundamental and clinical studies, it was concluded that CTM is an excellent antibiotic for the treatment of oral infections.
- Subjects :
- Adolescent
Adult
Cefotaxime blood
Cefotaxime therapeutic use
Cefotiam
Cellulitis drug therapy
Female
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Osteomyelitis drug therapy
Surgical Wound Infection prevention & control
Anti-Bacterial Agents therapeutic use
Bacterial Infections drug therapy
Cefotaxime analogs & derivatives
Mouth Diseases drug therapy
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0368-2781
- Volume :
- 35
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The Japanese journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 6292540