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Junin virus infection of Callithrix jacchus: pathologic features.

Junin virus infection of Callithrix jacchus: pathologic features.

Authors :
González PH
Laguens RP
Frigerio MJ
Calello MA
Weissenbacher MC
Source :
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 1983 Mar; Vol. 32 (2), pp. 417-23.
Publication Year :
1983

Abstract

Infection of Callithrix jacchus, a New World primate, with the prototype strain of Junin virus produced a severe disease. The animals developed multifocal hemorrhages and characteristic microscopic lesions such as meningoencephalitis, interstitial pneumonia, lymphocytic depletion of lymphatic tissue, hepatocytic necrosis, and a variable decrease in bone marrow cellularity. High virus concentrations correlated with lesions, and with the presence of viral antigenic determinants as revealed by immunofluorescent methods. With the exception of central nervous system damage, the morphological features and immunohistochemical and viral findings were similar to those recorded in human Argentine hemorrhagic fever.

Details

Language :
English
ISSN :
0002-9637
Volume :
32
Issue :
2
Database :
MEDLINE
Journal :
The American journal of tropical medicine and hygiene
Publication Type :
Academic Journal
Accession number :
6301303
Full Text :
https://doi.org/10.4269/ajtmh.1983.32.417