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Junin virus infection of Callithrix jacchus: pathologic features.
Junin virus infection of Callithrix jacchus: pathologic features.
- Source :
-
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 1983 Mar; Vol. 32 (2), pp. 417-23. - Publication Year :
- 1983
-
Abstract
- Infection of Callithrix jacchus, a New World primate, with the prototype strain of Junin virus produced a severe disease. The animals developed multifocal hemorrhages and characteristic microscopic lesions such as meningoencephalitis, interstitial pneumonia, lymphocytic depletion of lymphatic tissue, hepatocytic necrosis, and a variable decrease in bone marrow cellularity. High virus concentrations correlated with lesions, and with the presence of viral antigenic determinants as revealed by immunofluorescent methods. With the exception of central nervous system damage, the morphological features and immunohistochemical and viral findings were similar to those recorded in human Argentine hemorrhagic fever.
- Subjects :
- Animals
Arenaviruses, New World
Brain pathology
Fluorescent Antibody Technique
Hemorrhagic Fever, American microbiology
Hemorrhagic Fever, American pathology
Humans
Liver pathology
Lung pathology
Lymph Nodes pathology
Male
Monkey Diseases pathology
Callithrix microbiology
Callitrichinae microbiology
Hemorrhagic Fever, American veterinary
Monkey Diseases microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9637
- Volume :
- 32
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The American journal of tropical medicine and hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 6301303
- Full Text :
- https://doi.org/10.4269/ajtmh.1983.32.417