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[In vivo antibacterial activity of cefoperazone in intraperitoneal infections in mice].
- Source :
-
The Japanese journal of antibiotics [Jpn J Antibiot] 1983 Dec; Vol. 36 (12), pp. 3444-9. - Publication Year :
- 1983
-
Abstract
- The in vivo antibacterial activity of cefoperazone (CPZ) against systemic infections was studied in comparison with that of cefotiam (CTM) using beta-lactamase non-producing bacteria and producing bacteria. In vitro antibacterial activity of CPZ against Gram-positive bacteria was slightly inferior to that of CTM, but there was no significant difference between their in vivo activities. On the other hand, the therapeutic effect of CPZ against Gram-negative bacteria was nearly parallel to in vitro antibacterial activity and particularly was superior to that of CTM against cephalosporinase (CSase) producing bacteria. The ascitic levels of CPZ in mice infected with CSase producing bacteria were persisted longer, but those of CTM disappeared quickly after administration. This result appeared to reflect on the therapeutic effects of both drugs.
- Subjects :
- Animals
Ascitic Fluid metabolism
Ascitic Fluid microbiology
Bacteria enzymology
Cefoperazone metabolism
Cefotaxime analogs & derivatives
Cefotaxime therapeutic use
Cefotiam
Drug Evaluation, Preclinical
Male
Mice
Peritonitis microbiology
beta-Lactamases biosynthesis
Cefoperazone therapeutic use
Peritonitis drug therapy
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0368-2781
- Volume :
- 36
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Japanese journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 6325754