Sendai virus-specific T-cell clones: induction of cytolytic T cells by an anti-idiotypic antibody directed against a helper T-cell clone.

Authors :: Ertl HC
Finberg RW
Source :: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1984 May; Vol. 81 (9), pp. 2850-4.
Publication Year :: 1984
Abstract: We used a monoclonal anti-idiotypic antibody that is directed against a Sendai virus-specific helper T-cell clone to induce an anti-viral immune response in vivo. Splenocytes primed with the anti-idiotypic antibody mediated an antigen-specific cytolytic response. Preimmunization of mice with the anti-idiotypic antibody resulted in protection against a subsequent lethal infection with Sendai virus.

Subjects :: Animals
Antibodies, Anti-Idiotypic immunology
Clone Cells immunology
Immunity, Cellular
Mice
Receptors, Antigen, T-Cell immunology
Spleen immunology
T-Lymphocytes immunology
Immunoglobulin Idiotypes immunology
Parainfluenza Virus 1, Human immunology
T-Lymphocytes, Cytotoxic immunology
T-Lymphocytes, Helper-Inducer immunology

Language :: English
ISSN :: 0027-8424
Volume :: 81
Issue :: 9
Database :: MEDLINE
Journal :: Proceedings of the National Academy of Sciences of the United States of America
Publication Type :: Academic Journal
Accession number :: 6326148
Full Text :: https://doi.org/10.1073/pnas.81.9.2850

Full Text Access

Tools