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Peptidases involved in the inactivation of exogenous and endogenous enkephalins.
- Source :
-
Journal of neural transmission. Supplementum [J Neural Transm Suppl] 1983; Vol. 18, pp. 235-43. - Publication Year :
- 1983
-
Abstract
- Among the various cerebral enzyme activities able to hydrolyse the enkephalins into inactive fragments only two seem responsible for the metabolism of the endogenous opioid peptides: a dipeptidylcarboxypeptidase ("enkephalinase"), and a bestatin-sensitive aminopeptidase. Their inhibition by thiorphan and bestatin results in an antinociceptive effect observed in tests in which the nociceptive stimulation is probably accompanied by a concomittent release of enkephalins.
- Subjects :
- Aminopeptidases antagonists & inhibitors
Animals
Leucine analogs & derivatives
Leucine pharmacology
Mice
Neprilysin
Nociceptors metabolism
Rats
Thiorphan
Tiopronin analogs & derivatives
Tiopronin pharmacology
Aminopeptidases metabolism
Brain enzymology
Endopeptidases metabolism
Enkephalins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0303-6995
- Volume :
- 18
- Database :
- MEDLINE
- Journal :
- Journal of neural transmission. Supplementum
- Publication Type :
- Academic Journal
- Accession number :
- 6348211