In vivo localization of insulin binding to cells of the rat pancreas.

Authors :: Sakamoto C
Williams JA
Roach E
Goldfine ID
Source :: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) [Proc Soc Exp Biol Med] 1984 Apr; Vol. 175 (4), pp. 497-502.
Publication Year :: 1984
Abstract: The uptake of 125I-insulin by rat pancreas was studied in vivo. Following fixation and light microscope autoradiography, saturable uptake of 125I-insulin was quantitatively demonstrated on acinar and duct cells but not on blood vessels and islets of Langerhans. Electron microscopy revealed the localization of 125I-insulin to the basolateral cell membranes of acinar and duct cells.

Subjects :: Animals
Autoradiography
Insulin metabolism
Iodine Radioisotopes
Male
Microscopy, Electron
Pancreas ultrastructure
Rats
Rats, Inbred Strains
Insulin analogs & derivatives
Pancreas metabolism
Receptor, Insulin metabolism

Language :: English
ISSN :: 0037-9727
Volume :: 175
Issue :: 4
Database :: MEDLINE
Journal :: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Publication Type :: Academic Journal
Accession number :: 6369335
Full Text :: https://doi.org/10.3181/00379727-175-41827