Back to Search
Start Over
Antidiuresis and decreased sodium excretion during cyclo-oxygenase inhibition in the conscious dog.
- Source :
-
Renal physiology [Ren Physiol] 1983; Vol. 6 (2), pp. 53-62. - Publication Year :
- 1983
-
Abstract
- Studies were undertaken to further elucidate the role of endogenous prostaglandins in normal renal function in the awake dog. Meclofenamate (2 mg/kg and 2 mg/kg/h, i.v.) was administered after control measurements. Parallel time control experiments were also performed. Inhibition of renal prostaglandin synthesis was documented by significant reduction in urinary prostaglandin E2 excretion rate. Urine flow and sodium excretion were reduced by meclofenamate infusion. In addition, fractional excretion of sodium was reduced, implying enhanced sodium reabsorption during prostaglandin synthesis inhibition. Renal hemodynamics, glomerular filtration and systemic hemodynamics were unaffected. It is concluded that endogenous prostaglandin release is important in influencing sodium and water excretion in the conscious dog.
- Subjects :
- Animals
Cyclooxygenase Inhibitors
Dogs
Female
Glomerular Filtration Rate drug effects
Kidney metabolism
Kidney physiology
Potassium urine
Renal Circulation drug effects
Sodium urine
Diuresis drug effects
Kidney drug effects
Meclofenamic Acid pharmacology
Prostaglandins E physiology
ortho-Aminobenzoates pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0378-5858
- Volume :
- 6
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Renal physiology
- Publication Type :
- Academic Journal
- Accession number :
- 6407070
- Full Text :
- https://doi.org/10.1159/000172881