Back to Search
Start Over
Isolation and characterization of 15-hydroxylated metabolites of leukotriene C4.
- Source :
-
FEBS letters [FEBS Lett] 1983 Mar 21; Vol. 153 (2), pp. 253-6. - Publication Year :
- 1983
-
Abstract
- A polar metabolite of leukotriene C4 was formed by sequential conversions with soybean lipoxygenase I and liver peroxidase. The structure of this product was found to be 5(S), 15(S)-dihydroxy-6(R)-S-glutathionyl-7,9,13-trans-11-cis-eicosatetraenoic acid (15-hydroxy-delta 13-trans-leukotriene C3. The HPLC behaviour, the molar extinction coefficient and the biological activity of the metabolite are reported. Preliminary evidence suggests that this product is formed by mammalian tissues.
- Subjects :
- Animals
Chromatography, High Pressure Liquid
Guinea Pigs
Ileum drug effects
Kinetics
Lipoxygenase metabolism
Muscle Contraction drug effects
Plants enzymology
SRS-A isolation & purification
SRS-A pharmacology
Glycine max
Arachidonic Acids
Eicosanoids
Oligopeptides
SRS-A analogs & derivatives
SRS-A metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0014-5793
- Volume :
- 153
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 6413247
- Full Text :
- https://doi.org/10.1016/0014-5793(83)80618-8