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Novel kappa light-chain gene rearrangements in mouse lambda light chain-producing B lymphocytes.
- Source :
-
Nature [Nature] 1984 Feb 23-29; Vol. 307 (5953), pp. 749-52. - Publication Year :
- 1984
-
Abstract
- The genes that encode the immunoglobulin proteins made by B lymphocytes are made up of segments that are separately encoded in the germ-line genome and brought together by recombination during B-cell ontogeny. There are two types of immunoglobulin light chain, kappa and lambda, but only a single type is expressed in individual B cells. It is thought that kappa gene recombination precedes lambda gene recombination during B-cell ontogeny. We describe here unusual recombinations that have occurred in two lambda-producing B-cell lines and suggest that they are involved in the developmental switch from kappa to lambda gene expression in maturing B cells. These recombinations involve the J kappa-C kappa introns of V-J joined but nonfunctional kappa genes and a sequence that in the germ line occurs downstream of the C kappa exon (called RS, for recombining sequence).
Details
- Language :
- English
- ISSN :
- 0028-0836
- Volume :
- 307
- Issue :
- 5953
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 6422305
- Full Text :
- https://doi.org/10.1038/307749a0