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Sensitivity of Bloom syndrome fibroblasts to mitomycin C.

Sensitivity of Bloom syndrome fibroblasts to mitomycin C.

Authors :
Hook GJ
Kwok E
Heddle JA
Source :
Mutation research [Mutat Res] 1984 May-Jun; Vol. 131 (5-6), pp. 223-30.
Publication Year :
1984

Abstract

Lymphocytes and fibroblasts from people with Bloom syndrome, an autosomal recessive disorder associated with a predisposition to a wide variety of cancers, are known to be hypersensitive to ethylating agents as measured by sister chromatid exchange induction. Recently, hypersensitivity to cell killing by mitomycin C has also been reported in Bloom syndrome fibroblasts from three donors. We report here results which confirm the hypersensitivity of Bloom syndrome fibroblasts as measured by cell killing but show that they have a normal sensitivity to mitomycin C as measured by sister chromatid exchange induction. These results are discussed in terms of their relevance to the diversity of response of Bloom syndrome cells to mutagens, and the nature of the primary defect in Bloom syndrome.

Details

Language :
English
ISSN :
0027-5107
Volume :
131
Issue :
5-6
Database :
MEDLINE
Journal :
Mutation research
Publication Type :
Academic Journal
Accession number :
6429525
Full Text :
https://doi.org/10.1016/0167-8817(84)90029-4