[Multiplication of Mycobacterium tuberculosis in the organs of mice with a single exposure to cyclophosphamide].

The injection of cyclophosphamide, used as an immunomodulating agent in a dose of 100 mg/kg, into mice infected with M. tuberculosis induced an increase (a virulent culture) or a decrease (a culture with low virulence) in the multiplication of mycobacteria in the spleen. In mice infected with a virulent culture and protected from infection with streptomycin for 1 week cyclophosphamide induced a considerable decrease in the number of viable mycobacteria in the lungs by days 18-20 after infection.