Back to Search
Start Over
Compression-related defects from early amnion rupture: evidence for mechanical teratogenesis.
- Source :
-
The Journal of pediatrics [J Pediatr] 1981 Feb; Vol. 98 (2), pp. 292-7. - Publication Year :
- 1981
-
Abstract
- The features of 27 cases of limb/body wall deficiency (formerly termed cyllosomus and pleurosomus) were evaluated and the anomalies were interpreted as being band-related defects and/or compression-related defects. The latter included limb deficiency, body wall deficiency, neural tube defects, scoliosis, postural deformations, growth deficiency, and short umbilical cord. It is hypothesized that the single event of early amnion rupture can explain both the band-related defects and the compression-related defects. Experimental animal studies are in accord with this hypothesis; amnion puncture of rat fetuses during early gestation produces a comparable array of defects. The term amnion rupture sequence is suggested to describe the overall pattern of malformation that results from amnion rupture whether these defects are band related, compression related, or a combination of the two. There is considerable variation in the phenotype of amnion rupture sequence, with limb/body wall deficiency representing the more severe end of the spectrum. It is important to recognize and correctly diagnose amnion rupture sequence because it is usually a sporadic event.
- Subjects :
- Abdominal Muscles abnormalities
Animals
Constriction, Pathologic
Female
Fetal Membranes, Premature Rupture physiopathology
Humans
Infant, Newborn
Limb Deformities, Congenital
Male
Pregnancy
Rats
Umbilical Cord pathology
Uterus physiopathology
Abnormalities, Multiple etiology
Fetal Membranes, Premature Rupture complications
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3476
- Volume :
- 98
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 6450827
- Full Text :
- https://doi.org/10.1016/s0022-3476(81)80664-6