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Synthesis of dehydroepiandrosterone sulfatide and 16 alpha-halogenated steroids.
- Source :
-
Journal of pharmaceutical sciences [J Pharm Sci] 1981 Oct; Vol. 70 (10), pp. 1154-7. - Publication Year :
- 1981
-
Abstract
- Dehydroepiandrosterone sulfatide was prepared in a 68% yield by the reaction of 5-androstene-3 beta-ol-17-one 3 sulfate (silver salt) with dipalmitoyl alpha-iodopropylene glycol. The sulfatide was found to be a more potent inhibitor of human glucose-6-phosphate dehydrogenase than dehydroepiandrosterone. 16 alpha-Halogenated steroids also were prepared by direct halogenation of the steroid or indirect halogenation of an appropriate steroidal intermediate. Among various halogenated steroids, 16 alpha-bromoepiandrosterone was 50 times as potent as dehydroepiandrosterone as an inhibitor of glucose-6-phosphate dehydrogenase.
- Subjects :
- Animals
Dehydroepiandrosterone chemical synthesis
Erythrocytes enzymology
Glucosephosphate Dehydrogenase antagonists & inhibitors
Humans
Mice
Steroids, Chlorinated chemical synthesis
Steroids, Fluorinated chemical synthesis
Dehydroepiandrosterone analogs & derivatives
Steroids, Brominated chemical synthesis
Sulfoglycosphingolipids chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3549
- Volume :
- 70
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of pharmaceutical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 6457907
- Full Text :
- https://doi.org/10.1002/jps.2600701017