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Induction by degraded carrageenan of colorectal tumors in rats.

Authors :
Ashi KW
Inagaki T
Fujimoto Y
Fukuda Y
Source :
Cancer letters [Cancer Lett] 1978 Mar; Vol. 4 (3), pp. 171-6.
Publication Year :
1978

Abstract

Degraded carrageenan derived from the red seaweed Eucheuma spinosum was given to Sprague-Dawley rats through the diet, in drinking water or by stomach tube for up to 24 months. Carrageenan-induced squamous cell carcinomas, adenocarcinomas and adenomas in the colorectum were observed. Some rats had metastases to the regional lymph nodes of squamous cell carcinomas. These results show that degraded carrageenan is carcinogenic to the colorectum of the rat.

Subjects

Subjects :
Adenocarcinoma chemically induced
Adenoma chemically induced
Animals
Carcinoma, Squamous Cell chemically induced
Carrageenan administration & dosage
Colonic Neoplasms pathology
Female
Male
Neoplasms, Experimental chemically induced
Rats
Rectal Neoplasms pathology
Carcinogens
Carrageenan toxicity
Colonic Neoplasms chemically induced
Rectal Neoplasms chemically induced

Details

Language :
English
ISSN :
0304-3835
Volume :
4
Issue :
3
Database :
MEDLINE
Journal :
Cancer letters
Publication Type :
Academic Journal
Accession number :
647659
Full Text :
https://doi.org/10.1016/s0304-3835(78)94237-4
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