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Differential effects of chronic clorgyline and amfonelic acid on desensitization of striatal dopamine receptors.

Authors :
Meller E
Bohmaker K
Friedhoff AJ
Source :
Life sciences [Life Sci] 1984 Oct 29; Vol. 35 (18), pp. 1829-38.
Publication Year :
1984

Abstract

Chronic treatment of rats with the MAOI clorgyline significantly reduced the density (Bmax) of cortical beta-adrenergic receptors but did not alter either the Bmax or dissociation constant (Kd) of 3H-spiperone binding to striatal DA receptors. Clorgyline co-treatment also did not significantly affect either behavioral supersensitivity to apomorphine or the increase in 3H-spiperone binding induced by chronic haloperidol. In contrast, repeated treatment with the DA uptake inhibitor amfonelic acid elicited behavioral subsensitivity and reduced striatal 3H-spiperone binding. Furthermore, amfonelic acid co-treatment prevented haloperidol-induced behavioral and receptor binding changes. The possible relevance of these findings in relation to drug choice in clinical trials of receptor sensitivity modification are discussed.

Details

Language :
English
ISSN :
0024-3205
Volume :
35
Issue :
18
Database :
MEDLINE
Journal :
Life sciences
Publication Type :
Academic Journal
Accession number :
6492992
Full Text :
https://doi.org/10.1016/0024-3205(84)90534-4