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Enhancement of the immune response to hepatitis B surface antigen. In vivo administration of antiidiotype induces anti-HBs that expresses a similar idiotype.
- Source :
-
The Journal of experimental medicine [J Exp Med] 1984 Mar 01; Vol. 159 (3), pp. 655-65. - Publication Year :
- 1984
-
Abstract
- BALB/c mice receiving antiidiotype antibodies before the injection of hepatitis B surface antigen (HBsAg) generated an enhanced anti-HBs response. Mice given antiidiotype antibodies in a soluble form induced predominantly IgM anti-HBs, whereas alum-precipitated antiidiotype produced primarily IgG anti-HBs. Injection of antiidiotype antibodies alone induced anti-HBs that inhibited a common interspecies anti-HBs idiotype-antiidiotype reaction and recognized the group-specific determinant of HBsAg. These data support the view that antiidiotype antibodies may modulate the immune response to an infectious viral agent.
- Subjects :
- Animals
Binding, Competitive
Female
Hepatitis B microbiology
Hepatitis B Antibodies analysis
Hepatitis B Antibodies physiology
Hepatitis B Surface Antigens genetics
Humans
Immunoglobulin G biosynthesis
Immunoglobulin Idiotypes genetics
Mice
Mice, Inbred BALB C
Rabbits
Species Specificity
Viral Plaque Assay
Antibodies, Anti-Idiotypic administration & dosage
Hepatitis B immunology
Hepatitis B Antibodies biosynthesis
Hepatitis B Surface Antigens immunology
Immunoglobulin Idiotypes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1007
- Volume :
- 159
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 6607967
- Full Text :
- https://doi.org/10.1084/jem.159.3.655