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Prevention of posthysterectomy infection with a combination of preoperative vaginal and perioperative intravenous administration of metronidazole.
- Source :
-
Annales chirurgiae et gynaecologiae [Ann Chir Gynaecol] 1983; Vol. 72 (4), pp. 214-7. - Publication Year :
- 1983
-
Abstract
- In a prospective double-blind study 58 patients received 1000 mg of metronidazole vaginally 12--16 hours preoperatively and 500 mg intravenously during abdominal hysterectomy while 54 patients were treated with placebo. The lack of all operative site infections in the metronidazole group in comparison with 9 infections (17%) in the placebo group (P less than 0.01) proved the combined short-term vaginal and intravenous use of metronidazole to be efficacious in the prevention of posthysterectomy infections.
- Subjects :
- Adult
Aged
Bacteria, Anaerobic
Female
Humans
Infusions, Parenteral
Intraoperative Period
Metronidazole administration & dosage
Middle Aged
Urinary Tract Infections prevention & control
Vagina microbiology
Wound Infection prevention & control
Bacterial Infections prevention & control
Hysterectomy
Metronidazole therapeutic use
Premedication
Subjects
Details
- Language :
- English
- ISSN :
- 0355-9521
- Volume :
- 72
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Annales chirurgiae et gynaecologiae
- Publication Type :
- Academic Journal
- Accession number :
- 6638906