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Large luteal cells the source of luteal oxytocin in the sheep.

Authors :
Rodgers RJ
O'Shea JD
Findlay JK
Flint AP
Sheldrick EL
Source :
Endocrinology [Endocrinology] 1983 Dec; Vol. 113 (6), pp. 2302-4.
Publication Year :
1983

Abstract

To determine the cellular origin of oxytocin produced by the cyclical corpus luteum (CL) of the sheep, enriched fractions of enzymatically dispersed small and large luteal cells from 12 CL were prepared on a Ficoll 400 gradient. Oxytocin was measured by RIA. Large luteal cells contained 1.08 +/- (SD) 0.70 fg/cell oxytocin, which was congruent to 30 X the content of small luteal cells. Endothelial cells contained little if any oxytocin. During a 12-h incubation, large luteal cells produced 0.28 fg/cell.h oxytocin: small luteal cells did not produce measurable amounts of oxytocin. It is concluded that the large luteal cells are the source of the oxytocin produced by the CL of the sheep.

Details

Language :
English
ISSN :
0013-7227
Volume :
113
Issue :
6
Database :
MEDLINE
Journal :
Endocrinology
Publication Type :
Academic Journal
Accession number :
6641635
Full Text :
https://doi.org/10.1210/endo-113-6-2302