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[Clinical evaluation of an ampicillin suppository (KS-R1)].
- Source :
-
The Japanese journal of antibiotics [Jpn J Antibiot] 1983 Jul; Vol. 36 (7), pp. 1871-6. - Publication Year :
- 1983
-
Abstract
- Clinical evaluations of ampicillin (ABPC) suppository (KS-R1) were performed in 9 cases with infectious diseases in the pediatric field and the following results were obtained; When 2.7 mg/kg of KS-R1 was rectally administered to 1 case, the plasma levels of ABPC were 3.9 micrograms/ml at 15 minutes, 2.2 micrograms/ml at 30 minutes and 1.2 micrograms/ml at 60 minutes after administration. The urinary excretion rate within 6 hours was 5.0%. Clinical effects of KS-R1 were examined in 6 cases (4 cases of tonsillitis and 2 cases of urinary tract infection) at the dose of 20 approximately 50 mg/kg/day for 3 approximately 7 days. Clinical responses were excellent in 4 cases, good in 1 case and poor in 1 case (tonsillitis). As to the side effects, slight increase of eosinophil was observed in 1 case, but no diarrhea, perianal redness and eruption were observed. Since discharge ratio of KS-R1 within 5 minutes was 11.0%, the tolerance of KS-R1 was considered to be good. From the above results, KS-R1 is useful for treating the pediatric patients with various infections, who refuse to oral administration or are impossible to give oral administration because of vomiting and are multiple handicapped ones.
Details
- Language :
- Japanese
- ISSN :
- 0368-2781
- Volume :
- 36
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Japanese journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 6655816