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Cholecystokinin in the hypothalamo-hypophyseal system.

Authors :
Palkovits M
Kiss JZ
Beinfeld MC
Brownstein MJ
Source :
Brain research [Brain Res] 1984 May 07; Vol. 299 (1), pp. 186-9.
Publication Year :
1984

Abstract

Immunohistochemical studies on cholecystokinin-like (CCK-ir) substances in colchicine-pretreated rats demonstrated that in addition to CCK-ir cells in the magnocellular portion of the paraventricular nucleus. CCK-ir cells are also present among the parvocellular neurons. Radioimmunoassay of CCK after paraventricular lesions indicate that most, if not all, of the CCK in the posterior pituitary and in the median eminence originates from the paraventricular nucleus. It appears that CCK-fibers, like other neuropeptidergic fibers from the paraventricular nucleus (vasopressin, oxytocin, TRH, CRF) enter the medial basal hypothalamus through a common gate--the lateral retrochiasmatic area--in traveling to the median eminence.

Details

Language :
English
ISSN :
0006-8993
Volume :
299
Issue :
1
Database :
MEDLINE
Journal :
Brain research
Publication Type :
Academic Journal
Accession number :
6722568
Full Text :
https://doi.org/10.1016/0006-8993(84)90806-0