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Effect of potassium chloride supplements on upper gastrointestinal mucosa.
- Source :
-
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 1984 Jun; Vol. 35 (6), pp. 852-5. - Publication Year :
- 1984
-
Abstract
- Eight controlled 1- or 2-wk experiments involving 225 healthy male subjects and one study of 18 patients with hypertension, nine of whom were long-term users of a wax-matrix potassium chloride preparation, were conducted to evaluate the upper gastrointestinal safety of oral KCl supplements. All subjects in the short-term studies had normal upper gastrointestinal tracts. Subjects were examined again after at least 7 days of treatment with one of three commonly prescribed wax-matrix KCl tablets, KCl liquid, microencapsulated KCl, a potassium- sparer , or placebo. Some received an anticholinergic drug with treatment to induce delayed gastric motility. Diet and compliance to treatment regimens were controlled. Results indicate that upper mucosal injury, particularly erosions (43%) and ulcerations (11%), were more frequent after wax-matrix tablets. These changes occurred much less frequently after liquid KCl (0%), microencapsulated KCl (10.5% erosions, 1.2% ulcers), and the potassium-sparing drug (0%). More serious and more frequent lesions were associated with slowed motility. No occult bleeding was noted. Symptomatic complaints did not correlate with endoscopic findings. In the long-term study, patients with hypertension were examined endoscopically after 19 to 23 mo on KCl and again after 1 wk. Six of nine of the patients with hypertension treated for nearly 2 yr with a wax-matrix KCl supplement had significant lesions. One had developed ulceration after 7 days.(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- Delayed-Action Preparations
Endoscopy
Gastric Mucosa pathology
Glycopyrrolate adverse effects
Humans
Hypertension drug therapy
Intestinal Mucosa pathology
Male
Potassium Chloride administration & dosage
Random Allocation
Stomach Ulcer chemically induced
Time Factors
Gastric Mucosa drug effects
Intestinal Mucosa drug effects
Potassium Chloride adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0009-9236
- Volume :
- 35
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Clinical pharmacology and therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 6734038
- Full Text :
- https://doi.org/10.1038/clpt.1984.124