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Pharmacokinetics of cefoxitin administered by i.v. infusion to patients with a pleural effusion.
- Source :
-
European journal of clinical pharmacology [Eur J Clin Pharmacol] 1984; Vol. 26 (3), pp. 389-92. - Publication Year :
- 1984
-
Abstract
- The pharmacokinetics of cefoxitin was studied in 6 healthy volunteers and in 5 patients with a pleural effusion after administration of a single dose of 30 mg/kg i.v. infusion. The serum and pleural fluid concentrations of cefoxitin were determined microbiologically. The elimination half-life of the antibiotic from pleural fluid in all cases was 2-3 fold longer than from serum, which shows a difference between the kinetic elimination processes of the antibiotic from the two fluids. The slow elimination of cefoxitin from pleural fluid facilitates its accumulation in this compartment during a multiple dosage regimen.
Details
- Language :
- English
- ISSN :
- 0031-6970
- Volume :
- 26
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 6734700
- Full Text :
- https://doi.org/10.1007/BF00548772