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Pharmacokinetics of cefoxitin administered by i.v. infusion to patients with a pleural effusion.

Authors :
Otero MJ
Garcia MJ
Barrueco M
Dominguez-Gil A
Gomez F
Portugal Alvarez J
Source :
European journal of clinical pharmacology [Eur J Clin Pharmacol] 1984; Vol. 26 (3), pp. 389-92.
Publication Year :
1984

Abstract

The pharmacokinetics of cefoxitin was studied in 6 healthy volunteers and in 5 patients with a pleural effusion after administration of a single dose of 30 mg/kg i.v. infusion. The serum and pleural fluid concentrations of cefoxitin were determined microbiologically. The elimination half-life of the antibiotic from pleural fluid in all cases was 2-3 fold longer than from serum, which shows a difference between the kinetic elimination processes of the antibiotic from the two fluids. The slow elimination of cefoxitin from pleural fluid facilitates its accumulation in this compartment during a multiple dosage regimen.

Details

Language :
English
ISSN :
0031-6970
Volume :
26
Issue :
3
Database :
MEDLINE
Journal :
European journal of clinical pharmacology
Publication Type :
Academic Journal
Accession number :
6734700
Full Text :
https://doi.org/10.1007/BF00548772