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Effect of manganese treatment on the levels of neurotransmitters, hormones, and neuropeptides: modulation by stress.
- Source :
-
Environmental research [Environ Res] 1984 Aug; Vol. 34 (2), pp. 242-9. - Publication Year :
- 1984
-
Abstract
- Six weeks of daily intraperitoneal injection with manganese chloride (15 mg/kg body wt) reduced the normal weight gain of male Fischer-344 rats. This treatment depressed plasma testosterone and corticosterone levels, but prolactin levels were unaffected. The only significant changes in the levels of a variety of neuropeptides assayed in several regions were increases in the levels of hypothalamic substance P and pituitary neurotensin. Striatal serotonin, dopamine, and their metabolites were unchanged in manganese-exposed rats relative to saline-injected controls. However, the stress of injection combined with the effect of manganese appeared to significantly increase concentrations of striatal monoamines relative to uninjected controls.
- Subjects :
- Animals
Body Weight drug effects
Brain metabolism
Corticosterone blood
Injections, Intraperitoneal
Luteinizing Hormone blood
Male
Prolactin blood
Radioimmunoassay
Rats
Rats, Inbred F344
Stress, Physiological
Testosterone blood
Brain drug effects
Manganese pharmacology
Nerve Tissue Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0013-9351
- Volume :
- 34
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Environmental research
- Publication Type :
- Academic Journal
- Accession number :
- 6745226
- Full Text :
- https://doi.org/10.1016/0013-9351(84)90092-6