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Doxorubicin-enhanced skin reaction after whole-body electron-beam irradiation for leukemia cutis.
- Source :
-
Mayo Clinic proceedings [Mayo Clin Proc] 1980 Nov; Vol. 55 (11), pp. 711-5. - Publication Year :
- 1980
-
Abstract
- This is the first report of doxorubicin (Adriamycin) interacting with whole-body electro-beam irradiation to produce generalized toxic epidermal necrolysis. The patient was a 32-year-old woman with acute myelomonocytic leukemia and leukemia cutis. The severe dermatitis obscured clinical recognition of concomitant pseudomembranous colitis and contributed to the patient's death during management of toxic megacolon. Suggestions are made for minimizing this occurrence in future patients treated in a similar fashion.
- Subjects :
- Adult
Antineoplastic Agents administration & dosage
Doxorubicin administration & dosage
Female
Humans
Leukemia complications
Leukemia, Myeloid, Acute drug therapy
Radiotherapy, High-Energy
Skin Neoplasms complications
Doxorubicin adverse effects
Epidermolysis Bullosa chemically induced
Leukemia radiotherapy
Leukemia, Myeloid, Acute complications
Radiation Tolerance
Skin Neoplasms radiotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 0025-6196
- Volume :
- 55
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Mayo Clinic proceedings
- Publication Type :
- Academic Journal
- Accession number :
- 6777613