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Effects of synthetic LH-RH and TRH on pituitary function in anencephalic infants.
- Source :
-
Gynecologic and obstetric investigation [Gynecol Obstet Invest] 1980; Vol. 11 (4), pp. 231-6. - Publication Year :
- 1980
-
Abstract
- The pituitary endocrine function in 4 anencephalic infants was studied by measuring the concentrations of growth hormone, prolactin, thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in umbilical venous serum. There was no significant difference in hormone levels between the anencephalic and normal infants. The response of FSH and LH was negative after administration of 10 micrograms of luteinizing hormone-releasing hormone. The TSH levels after administration of 50 micrograms of TRH elevated about 4- to 6-fold over pre-administration levels. These results indicate that the hypothalamo-pituitary axis of the human fetus initiates its function from mid-pregnancy; TSH may have an autoregulating system of the pituitary itself.
- Subjects :
- Female
Follicle Stimulating Hormone blood
Gonadotropin-Releasing Hormone pharmacology
Growth Hormone blood
Humans
Hypothalamus physiopathology
Infant, Newborn
Luteinizing Hormone blood
Pituitary Function Tests
Pregnancy
Prolactin blood
Thyrotropin blood
Thyrotropin-Releasing Hormone pharmacology
Anencephaly physiopathology
Pituitary Gland physiopathology
Pituitary Hormones blood
Subjects
Details
- Language :
- English
- ISSN :
- 0378-7346
- Volume :
- 11
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Gynecologic and obstetric investigation
- Publication Type :
- Academic Journal
- Accession number :
- 6778780
- Full Text :
- https://doi.org/10.1159/000299842