Immunological study of typhoid fever in man. II Cell-mediated immune response.

The development of cell-mediated immune response to lipopolysaccharide and Barber protein from Salmonella typhi was investigated in patients suffering from typhoid fever. The cell-mediated immunity as measured by the leukocyte adherence inhibition test, was demonstrable in 77% of patients with typhoid fever but only in 5.6% of healthy controls. It was found that cell-mediated immune response appeared after the first week of illness and persisted for at least 4 weeks. The time course development of cell-mediated immune response and humoral immune response was correlated but the magnitude of each response was independent on one another.