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Toxicity, antitumour and haematological effects of 1,2-anhydro-6-bromogalactitol and d-mannitol: a comparison with the related dibromo- and dianhydro-derivatives.
- Source :
-
European journal of cancer & clinical oncology [Eur J Cancer Clin Oncol] 1982 Jun; Vol. 18 (6), pp. 573-7. - Publication Year :
- 1982
-
Abstract
- 1,2-Anhydro-6-bromo-6-deoxygalactitol (BrEpG) and its D-mannitol analogue (BrEpM) intermediary metabolites in the conversion of dibromodulcitol (DBD) and dibromomannitol (DBM) into dianhydrogalactitol (DAG) and dianhydromannitol (DAM) have been prepared. The three types of derivative of each hexitol have been compared in their toxicities towards mice, tumour inhibitory activities against the Walker carcinosarcoma and haematological effects in rats. The bromoepoxides showed intermediate potency in all tests. The galactitol derivatives were always more potent than their mannitol counterparts. The mannitol derivatives were selectively myelosuppressive, being twice as toxic towards granulocytes as towards lymphocytes. The lymphotoxic activity of DBM, in particular, relative to its other toxic effects was particularly mild. These differences have been ascribed principally to the more rapid reactivity of DAG compared with DAM towards target nucleophiles, modulated by the influence of the bromine substituent on the transport properties of the dibromo- and bromoepoxy-derivatives.
- Subjects :
- Animals
Antineoplastic Agents therapeutic use
Antineoplastic Agents toxicity
Dianhydrogalactitol therapeutic use
Dianhydrogalactitol toxicity
Lethal Dose 50
Leukopenia chemically induced
Mannitol therapeutic use
Mannitol toxicity
Mice
Mitobronitol therapeutic use
Mitobronitol toxicity
Mitolactol therapeutic use
Mitolactol toxicity
Rats
Carcinoma 256, Walker drug therapy
Mannitol analogs & derivatives
Mitobronitol analogs & derivatives
Mitolactol analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0277-5379
- Volume :
- 18
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- European journal of cancer & clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 6811281
- Full Text :
- https://doi.org/10.1016/0277-5379(82)90227-9