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Degeneration and regeneration of the olfactory epithelium after olfactory bulb ablation in the pig: a morphological and electrophysiological study.
- Source :
-
Quarterly journal of experimental physiology (Cambridge, England) [Q J Exp Physiol] 1981 Oct; Vol. 66 (4), pp. 533-40. - Publication Year :
- 1981
-
Abstract
- The olfactory bulbs were removed surgically from Large White male and female pigs, 10--12 weeks of age. At intervals of 3, 7, 14, 42 and 84 d after bulbectomy, the pigs were sacrificed and portions of olfactory mucosa were removed from the ethmoturbinate and septum regions of the nasal cavity; olfactory mucosa was also removed from unoperated pigs. A piece of each tissue sample was processed for light microscopy. The remaining tissue was placed in Ringer-Locke solution, saturated with O2/CO2 at room temperature, and the electrical activity of the olfactory epithelium was investigated in vitro by passing a stimulus of butyl acetate vapour over the epithelium. Slow negative potential changes (electro-olfactogram, e.o.g.) induced by butyl acetate were recorded. During the first two weeks after bulbectomy there was a rapid decrease in the height of the olfactory epithelium associated with the disappearance of the e.o.g. response. However by 42 and 84 d after bulbectomy, partial recovery of the height and some electrical activity of the olfactory mucosa had occurred. In some pigs, the insertion of a stainless steel lining over the cribriform plate to prevent any association of regenerating axons with forebrain tissue had no effect on the regenerative characteristics studied.
Details
- Language :
- English
- ISSN :
- 0144-8757
- Volume :
- 66
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Quarterly journal of experimental physiology (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 6914685
- Full Text :
- https://doi.org/10.1113/expphysiol.1981.sp002594