Anterior segment mesenchymal dysgenesis: probable linkage to the MNS blood group on chromosome 4.

Authors :: Ferrell RE
Hittner HM
Kretzer FL
Antoszyk JH
Source :: American journal of human genetics [Am J Hum Genet] 1982 Mar; Vol. 34 (2), pp. 245-9.
Publication Year :: 1982
Abstract: Thirty-seven blood samples were analyzed for linkage from members of a single family with an anterior segment mesenchymal dysgenesis (ASMD1) with variable expressivity affecting members of at least six generations. Maximum-likelihood analysis for linkage between ASMD1 and 14 biochemical and serological markers in the family showed a probable linkage between ASMD1 and the MNS blood group on the long arm of chromosome 4 (Z = 2.36 at a recombination fraction of .09).

Subjects :: Descemet Membrane abnormalities
Female
Genes, Dominant
Genetic Linkage
Genetic Markers
Humans
Male
Pedigree
Phenotype
Syndrome
Chromosome Mapping
Chromosomes, Human, 4-5
Corneal Dystrophies, Hereditary genetics
MNSs Blood-Group System genetics

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