Back to Search
Start Over
Properties of reference Escherichia coli endotoxin and its phthalylated derivative in humans.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1981 Oct; Vol. 144 (4), pp. 329-36. - Publication Year :
- 1981
-
Abstract
- The properties of a reference bacterial endotoxin prepared from Escherichia coli and its phthalylated derivative were studied in normal human volunteers infected intravenously with the compounds. The minimal pyrogenic dose of the reference endotoxin is about 0.1-0.5 ng/kg. The increase in white blood cell count, absolute granulocyte count, absolute immature granulocyte count, and concentrations of serum amyloid A, cortisol, and growth hormone was directly related to the concentration of reference endotoxin administered. Phthalylated reference endotoxin up to 1,000 ng/kg (at least 500 ng of the patent compound/kg) was administered to normal human volunteers without significant changes in temperature, white blood cell count, absolute granulocyte count, and concentrations of serum amyloid A, cortisol, and growth hormone. Thus, this study defines biologic properties of the new reference bacterial endotoxin in humans and demonstrates effective detoxification by phthalylation of the present compound.
- Subjects :
- Adult
Endotoxins administration & dosage
Female
Fever chemically induced
Growth Hormone blood
Humans
Hydrocortisone blood
Leukocyte Count
Lipopolysaccharides administration & dosage
Lipopolysaccharides standards
Male
Phthalic Acids administration & dosage
Phthalic Acids standards
Serum Amyloid A Protein analysis
Endotoxins standards
Escherichia coli
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 144
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 7026693
- Full Text :
- https://doi.org/10.1093/infdis/144.4.329