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Prediction of early relapse after pimozide discontinuation by response to d-amphetamine during pimozide treatment.
- Source :
-
Biological psychiatry [Biol Psychiatry] 1982 Feb; Vol. 17 (2), pp. 233-42. - Publication Year :
- 1982
-
Abstract
- Thirteen schizophrenic patients underwent a d-amphetamine infusion while being treated with pimozide, an antipsychotic agent and a relatively specific dopamine (DA) blocker. Six patients who showed an acute increase in psychosis with d-amphetamine relapsed within 3 months after pimozide withdrawal. Of the seven patients who did not change in psychosis with d-amphetamine, six did not relapse after pimozide discontinuation (Fisher's exact test, p less than 0.005). Retrospectively, the psychosis-inducing effects of d-amphetamine were found to be predictive of psychotic exacerbation following subsequent pimozide withdrawal. Pimozide failed to block the psychotogenic effects of d-amphetamine in six patients indicating that other mechanisms besides DA may play a role in psychotic decompensation. The d-amphetamine infusion paradigm should be studied further to determine its clinical value for identifying which schizophrenic patients are at risk for relapse after discontinuation of neuroleptic treatment.
- Subjects :
- Acute Disease
Adolescent
Adult
Dopamine physiology
Female
Humans
Male
Middle Aged
Pimozide administration & dosage
Receptors, Dopamine drug effects
Recurrence
Retrospective Studies
Risk
Schizophrenia physiopathology
Schizophrenic Psychology
Dextroamphetamine pharmacology
Pimozide therapeutic use
Schizophrenia drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0006-3223
- Volume :
- 17
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 7074181