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Role of adrenal medulla in morphine-induced hyperthermia through central action.

Authors :
Wallenstein MC
Source :
British journal of pharmacology [Br J Pharmacol] 1982 Aug; Vol. 76 (4), pp. 565-8.
Publication Year :
1982

Abstract

The role of the adrenal glands, in morphine-induced hyperthermia was studied in normal, chemically-sympathectomized, adrenalectomized, adrenal-demedullated or splanchnicotomized rats. 2. In restrained female rats, 5 mg/kg morphine produced hyperthermia whereas 20 mg/kg and 40 mg/kg produced hyperthermia. 3. After adrenalectomy, 5 mg/kg morphine did not produce hyperthermia. 4. After adrenal-demedullation or adrenal-denervation (splanchnicotomy), 5 mg/kg morphine did not produce hyperthermia. 5. The results suggest that, in the rat, the adrenal medulla plays an important role in morphine-induced hyperthermia, and that morphine acts centrally to stimulate the medulla.

Details

Language :
English
ISSN :
0007-1188
Volume :
76
Issue :
4
Database :
MEDLINE
Journal :
British journal of pharmacology
Publication Type :
Academic Journal
Accession number :
7104526
Full Text :
https://doi.org/10.1111/j.1476-5381.1982.tb09255.x