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Alterations of the tryptophan--nicotinic acid metabolism in vitiligo.
- Source :
-
Acta vitaminologica et enzymologica [Acta Vitaminol Enzymol] 1982; Vol. 4 (3), pp. 237-43. - Publication Year :
- 1982
-
Abstract
- Tryptophan metabolism "via kynurenine" is altered in vitiligo: after a load of the amino acid the urinary excretion of 3-hydroxykynurenine and 3-hydroxyanthranilic acid is decreased, whereas that of xanthurenic acid and its 8-methyl ether is increased. The excretory values of the metabolites suggest a deficiency of the activity of kynurenine hydroxylase and kynunerinase, the enzymes involved in the metabolism of 3-hydroxykynurenine and 3-hydroxyanthranilic acid. The reduced excretion of 3-hydroxykynurenine, a tryptophan metabolite involved in melanin biosynthesis, may indicate a smaller utilization of tryptophan in the biogenesis of the melanins.
- Subjects :
- 3-Hydroxyanthranilic Acid urine
Adult
Female
Humans
Hydrolases urine
Kynurenic Acid analogs & derivatives
Kynurenic Acid urine
Kynurenine analogs & derivatives
Kynurenine metabolism
Kynurenine urine
Kynurenine 3-Monooxygenase
Male
Melanins biosynthesis
Mixed Function Oxygenases urine
Models, Biological
Xanthurenates urine
Niacin metabolism
Tryptophan metabolism
Vitiligo metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0300-8924
- Volume :
- 4
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Acta vitaminologica et enzymologica
- Publication Type :
- Academic Journal
- Accession number :
- 7148608