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[The pattern of cerebrospinal fluid proteins in infants and children. Determination of normal values (author's transl)].
- Source :
-
Archives francaises de pediatrie [Arch Fr Pediatr] 1981 Jan; Vol. 38 (1), pp. 3-9. - Publication Year :
- 1981
-
Abstract
- Cerebrospinal fluid (CSF) protein values were measured in 652 children between the ages of 1 day and 17 years, allowing the authors to define the dynamics of the blood-brain barrier under normal conditions and during inflammation of the nervous system. The ratio of CSF albumin/serum albumin (whose upper limit was 0.65 in the study) was the best sign of alteration of blood-brain barrier permeability. The CSF IgG level, whose upper limit was 0.85 (for serum IgG between 10 and 14 g/l) is the most useful criterion for detecting an intra-thecal synthesis of IgG. Six patterns of CSF proteins are defined on the basis of immunochemical and electrophoretic studies. The ratio of CSF albumin/serum albumin and the CSF IgG level must be compared to the electrophoretic pattern of CSF proteins in order to better characterize one aspect of the blood-brain barrier under normal and pathologic conditions of the central nervous system.
- Subjects :
- Adolescent
Cerebrospinal Fluid Proteins blood
Child
Child, Preschool
Electrophoresis, Agar Gel
Humans
Immunoglobulin G analysis
Immunoglobulin G cerebrospinal fluid
Infant
Infant, Newborn
Nervous System Diseases cerebrospinal fluid
Serum Albumin cerebrospinal fluid
Cerebrospinal Fluid Proteins analysis
Subjects
Details
- Language :
- French
- ISSN :
- 0003-9764
- Volume :
- 38
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Archives francaises de pediatrie
- Publication Type :
- Academic Journal
- Accession number :
- 7224799