[Study of the mechanisms of action of lipid peroxidation products on the permeability of bilayer lipid membranes].

It has been shown that introduction of the fraction of phosphatydylethanolamine enriched with primary products of peroxidation-hydroperoxides-into bilayer lipid membrane (BLM) results in the rise of permeability of BLM towards H+ and K+ ions. The effect depends on the background permeability of the membrane and on the introduction method of the fraction enriched with hydroperoxides (FEHP) into monolayer or into both layers of BLM. Absence of the effect while including hydroperoxides into the membrane monolayer with low background conductivity and growth of BLM conductivity when introducing FEHP into both monolayers of the membrane permits a substantiation of the "Cluster" mechanisms of the membrane permeability increase with the accumulation of phospholipid hydroperoxides.