Back to Search Start Over

Preliminary studies on the absorption, distribution and excretion of 2-(7'theophyllinemethyl)-1,3-dioxolane in the rat.

Authors :
Franzone JS
Cravanzola C
Masera F
Source :
Il Farmaco; edizione scientifica [Farmaco Sci] 1981 Mar; Vol. 36 (3), pp. 220-4.
Publication Year :
1981

Abstract

Preliminary studies in the rat were carried out on the absorption, distribution and excretion of 2-(7'-theophyllinemethyl)-1,3-dioxolane (ABC 12/3), a new compound with anti-bronchospastic activity. Our results show that ABC 12/3 is rapidly absorbed and remains in the blood for about 6 hours. The distribution of this compound in the various tissues appears quite rapid, reaching good concentrations in the lung. Urinary excretion is complete within 12 hours after the administration of the compound, which is metabolized like a theophylline derivative.

Details

Language :
English
ISSN :
0430-0920
Volume :
36
Issue :
3
Database :
MEDLINE
Journal :
Il Farmaco; edizione scientifica
Publication Type :
Academic Journal
Accession number :
7227505