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[Plasma dopamine-beta-hydroxylase activity in pheochromocytoma (author's transl)].

Authors :
Guilland JC
Caillard B
Putelat R
Klepping C
Klepping J
Malval M
Source :
Annales d'endocrinologie [Ann Endocrinol (Paris)] 1980 Jan-Feb; Vol. 41 (1), pp. 43-9.
Publication Year :
1980

Abstract

In 3 patients with proved pheochromocytoma, circulating catecholamine concentrations, vanillylmandelic acid and total free catecholamine urinary excretion, dopamine-beta-hydroxylase activities in plasma were measured the day before surgery, during the removal of the tumour and postoperatively. Following the removal of the pheochromocytoma, all these parameters declined with a different rate, possibly related to the half-life proper to each molecule. The results showing a decrease in plasma D beta H activities after the removal of the tumors are in good accordance with most authors. The mechanism and the meaning of catecholamines release from non-innervated tumor-cells remain to be elucidated. By considering these three cases, it does not seem that the evolution of D beta H activity after removal of the tumor is dependent upon the fact that the pheochromocytoma releases preferentially either epinephrine or nephinephrine.

Details

Language :
French
ISSN :
0003-4266
Volume :
41
Issue :
1
Database :
MEDLINE
Journal :
Annales d'endocrinologie
Publication Type :
Academic Journal
Accession number :
7396393