Back to Search
Start Over
Identification of dihydrofolate reductase in human central-nervous-system tumours.
- Source :
-
Lancet (London, England) [Lancet] 1978 Jan 28; Vol. 1 (8057), pp. 184-5. - Publication Year :
- 1978
-
Abstract
- Ten primary and two metastatic central-nervous system (C.N.S.) tumours were assayed. They all contained dihydrofolate reductase. This finding provides a biochemical rationale for antifolate therapy of C.N.S. tumours by methotrexate.
- Subjects :
- Adenocarcinoma enzymology
Astrocytoma enzymology
Brain enzymology
Brain Chemistry
Brain Neoplasms drug therapy
Breast Neoplasms enzymology
Bronchial Neoplasms enzymology
Female
Glioblastoma enzymology
Glioma enzymology
Humans
Meningeal Neoplasms enzymology
Meningioma enzymology
Methotrexate therapeutic use
Neoplasm Metastasis
Brain Neoplasms enzymology
Tetrahydrofolate Dehydrogenase analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0140-6736
- Volume :
- 1
- Issue :
- 8057
- Database :
- MEDLINE
- Journal :
- Lancet (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 74608
- Full Text :
- https://doi.org/10.1016/s0140-6736(78)90615-3