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[Endogenous digitalis-like factor in liver cirrhosis and cholestasis].
- Source :
-
Zeitschrift fur Gastroenterologie [Z Gastroenterol] 1993 Feb; Vol. 31 Suppl 2, pp. 20-3. - Publication Year :
- 1993
-
Abstract
- Endogenous digitalis-like factor (EDLF), an inhibitor of membrane Na+/K(+)-ATPase, is discussed to be involved in the pathogenesis of cirrhogenic portal hypertension, ascites formation and development of functional hepatorenal failure. Therefore, we investigated the serum content of this mediator in patients with liver cirrhosis Child-Pugh stage A, B, and C (n = 27) by means of enzyme immunoassay with a specific digoxin antibody. Furthermore, a correlation analysis was performed in order to find out correlations between signs of cell injury, cholestasis, synthetic cell function, ascites formation, and hepatorenal failure. Our results demonstrate that EDLF is significantly elevated in Child C cirrhosis (0.61 +/- 0.15 ng/ml) in comparison to Child A cirrhosis (0.013 +/- 0.2 ng/ml) and is also higher than in Child B cirrhosis (0.23 +/- 0.25 ng/ml). In patients without ascites EDLF (0.056 +/- 0.19 ng/ml) differs significantly from that of patients with non-complicated ascites (0.156 +/- 0.176 ng/ml) and from that of patients with therapy refractory ascites (0.66 +/- 0.17 ng/ml) or hepatorenal failure (1.56 ng/ml). There are no correlations between EDLF and renal function. Significant correlations were demonstrated for cholestasis (serum bilirubin), synthesis function (serum protein, Quick's value, cholinesterase, fibrinogen, albumin), and the degree of portasystemic encephalopathy (number connection test). We conclude that EDLF may act as a mediator in the process of progressive portal hypertension and its complications due to cirrhosis. This process of progression is caused by the inhibition of Na+/K(+)-ATPase, vasoconstriction, and endothelin secretion.
- Subjects :
- Adult
Ascites physiopathology
Bilirubin blood
Cardenolides
Female
Hepatic Encephalopathy physiopathology
Hepatorenal Syndrome physiopathology
Humans
Hypertension, Portal physiopathology
Immunoenzyme Techniques
Kidney Function Tests
Liver physiopathology
Liver Cirrhosis classification
Liver Function Tests
Male
Prothrombin Time
Serum Albumin metabolism
Sodium-Potassium-Exchanging ATPase antagonists & inhibitors
Sodium-Potassium-Exchanging ATPase physiology
Blood Proteins physiology
Digoxin
Enzyme Inhibitors
Liver Cirrhosis physiopathology
Saponins
Subjects
Details
- Language :
- German
- ISSN :
- 0044-2771
- Volume :
- 31 Suppl 2
- Database :
- MEDLINE
- Journal :
- Zeitschrift fur Gastroenterologie
- Publication Type :
- Academic Journal
- Accession number :
- 7483706