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A protective role of gamma delta T cells in primary infection with Listeria monocytogenes in autoimmune non-obese diabetic mice.
- Source :
-
Immunology [Immunology] 1995 Oct; Vol. 86 (2), pp. 199-205. - Publication Year :
- 1995
-
Abstract
- We investigated the host defense mechanism in primary infection with Listeria monocytogenes in non-obese diabetic (NOD) mice at pre-diabetic stage showing an impaired responsiveness of the alpha beta T cells to T-cell receptor (TCR) triggering. The NOD mice showed a deteriorated resistance at the late stage after an intraperitoneal infection with L. monocytogenes compared with BALB/c and C57BL/6 mice as assessed by bacterial growth in organs. Consistent with our previous findings, a prominent increase in number of gamma delta T cells was evident at the early stage after infection, while generation of Listeria-specific alpha beta T cells was impaired in these mice. In vivo administration of anti-TCR gamma delta monoclonal antibody (mAb) allowed L. monocytogenes to grow exaggeratedly in the NOD mice. These results imply that gamma delta T cells may be mainly involved in protection against primary infection with L. monocytogenes in NOD mice.
- Subjects :
- Animals
Cell Division
Disease Susceptibility
Female
Immunity, Cellular
Kinetics
Listeria monocytogenes growth & development
Liver microbiology
Mice
Mice, Inbred BALB C
Mice, Inbred NOD
Receptors, Antigen, T-Cell, alpha-beta
Autoimmune Diseases immunology
Diabetes Mellitus, Type 1 immunology
Listeriosis immunology
Receptors, Antigen, T-Cell, gamma-delta
T-Lymphocyte Subsets immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0019-2805
- Volume :
- 86
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 7490118