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Functional effects of a family of galanin antagonists on the cardiovascular system in anaesthetised cats.
- Source :
-
Regulatory peptides [Regul Pept] 1994 Apr 14; Vol. 51 (1), pp. 17-23. - Publication Year :
- 1994
-
Abstract
- Previous studies have shown that injection of galanin (GAL: 6.2 nmol/kg) causes prolonged inhibition of cardiac vagal action in anaesthetised cats. Stimulation of the cardiac sympathetic nerve (16 Hz for 5 min) also produces inhibition of cardiac vagal action, an effect which has been proposed to be due to the release of endogenous GAL from sympathetic nerves. In a previous study we tested galantide (M15) and in this study we compared galantide with two other GAL antagonists for their GAL antagonist activity in our experimental model. Each of these incorporate the N-terminal fragment GAL 1-13 and a C-terminal portion of another bioactive peptide and all are C-terminally amidated. GAL 1-13 Substance P 5-11 amide (galantide: M15: 62 nmol/kg and 156 nmol/kg), GAL 1-13 Spantide amide (C7: 156 nmol/kg) and GAL 1-13 NPY 24-36 amide (M32a: 62 nmol/kg) all significantly reduced the cardiac vagal inhibitory effect of exogenous GAL and also reduced the effect of sympathetic stimulation on subsequent cardiac vagal slowing, giving strong support to our hypothesis that GAL is involved in this phenomenon. No antagonist reduced the depressor effect of GAL. This study demonstrates the GAL antagonist properties of these agents on autonomic neuroeffector functions making them useful tools in elucidating further functions of endogenous GAL.
- Subjects :
- Analysis of Variance
Animals
Aortic Bodies drug effects
Blood Pressure drug effects
Cats
Electric Stimulation
Female
Galanin
Heart innervation
Male
Substance P pharmacology
Sympathetic Nervous System physiology
Vagus Nerve drug effects
Vagus Nerve physiology
Heart Conduction System drug effects
Neuropeptides antagonists & inhibitors
Peptide Fragments pharmacology
Peptides antagonists & inhibitors
Peptides pharmacology
Substance P analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0167-0115
- Volume :
- 51
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Regulatory peptides
- Publication Type :
- Academic Journal
- Accession number :
- 7518601
- Full Text :
- https://doi.org/10.1016/0167-0115(94)90130-9