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Monoclonal expansion of large granular lymphocytes with a CD4+ CD8dim+/- phenotype associated with hairy cell leukemia.
- Source :
-
Haematologica [Haematologica] 1995 Mar-Apr; Vol. 80 (2), pp. 146-9. - Publication Year :
- 1995
-
Abstract
- Peripheral blood lymphoid cell expansions with an unusual CD3+, CD4+, CD8dim+/-, CD11b+, CD57+ immunophenotype have recently been reported. They frequently have the morphology of large granular lymphocytes (LGL) and can be either monoclonal or polyclonal. Their significance is still unclear and no association with hematological neoplasms has been described. We report the case of a patient with a monoclonal expansion of LGL associated with a B-cell-derived hairy cell leukemia. The two lymphoid clones were not physically associated since T-LGL were found in the peripheral blood and hairy cells were detected in the bone marrow and kidney.
- Subjects :
- Aged
Antigens, Differentiation, T-Lymphocyte analysis
Antigens, Neoplasm analysis
B-Lymphocytes pathology
Bone Marrow pathology
CD11 Antigens analysis
CD4 Antigens analysis
CD57 Antigens
CD8 Antigens analysis
Humans
Immunophenotyping
Kidney pathology
Leukemia, Hairy Cell blood
Lymphocyte Activation
Male
Neoplastic Stem Cells pathology
Antigens, CD analysis
Clone Cells pathology
Leukemia, Hairy Cell pathology
T-Lymphocyte Subsets
Subjects
Details
- Language :
- English
- ISSN :
- 0390-6078
- Volume :
- 80
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Haematologica
- Publication Type :
- Academic Journal
- Accession number :
- 7543070