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[The effect of diazepam on the activity of carboxypeptidase N and the angiotensin-converting enzyme in sections of the brain of rats with differing normal emotionality and in emotional stress].
- Source :
-
Fiziologicheskii zhurnal imeni I.M. Sechenova [Fiziol Zh Im I M Sechenova] 1994 Dec; Vol. 80 (12), pp. 108-13. - Publication Year :
- 1994
-
Abstract
- Diazepam increased the carboxypeptidase H activity and decreased the angiotensin converting enzyme activity in the rat brain. Joint action of diazepam and emotional stress changed the carboxypeptidase H activity to the least extent and the angiotensin converting enzyme activity to the utmost extent as compared to the agents' separate effects. The role of both enzymes in the diazepam effect is discussed.
- Subjects :
- Analysis of Variance
Animals
Anti-Anxiety Agents therapeutic use
Brain enzymology
Brain Chemistry drug effects
Chronic Disease
Diazepam therapeutic use
Drug Evaluation, Preclinical
Lysine Carboxypeptidase analysis
Male
Peptidyl-Dipeptidase A analysis
Rats
Stress, Psychological enzymology
Anti-Anxiety Agents pharmacology
Brain drug effects
Diazepam pharmacology
Emotions drug effects
Lysine Carboxypeptidase drug effects
Peptidyl-Dipeptidase A drug effects
Stress, Psychological drug therapy
Subjects
Details
- Language :
- Russian
- ISSN :
- 1027-3646
- Volume :
- 80
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Fiziologicheskii zhurnal imeni I.M. Sechenova
- Publication Type :
- Academic Journal
- Accession number :
- 7550425